P-538 The association between Clinical Pregnancy Rate in IVF-Cycles and Endometrial Receptivity based on a Novel Ultrasonographic Endometrial Receptivity Scoring System

Abstract Study question Our study was aimed towards determining whether Ultrasound based assessment of Endometrial features like blood flow, echopattern and thickness, can correlate with IVF pregnancy rates. Summary answer It found that Clinical Pregnancy Rate in cycles improved as the Receptivity Score increased. What is known already Establishing a successful depends on endometrium embryo. Suboptimal endometrial receptivity account for one-third implantation failures. Despite in-depth understanding processes associated embryo-endometrial crosstalk, little progress has been achieved diagnosis treatments suboptimal receptivity. Continuously mature embryo laboratory operation technology culture have significantly quality embryos. In addition, because its accuracy non-invasiveness, transvaginal ultrasound widely used field assisted reproduction, not only monitoring follicles, but also evaluating this technique help achieving design, size, duration This prospective carried out from 2020 to 2022 which 275 participants were recruited. Exclusion Criteria following: congenital uterine anomalies or acquired diseases, submucosal myoma, intrauterine adhesion, effusion adenomyosis, hydrosalpinx; endometriosis; pre-implantation genetic test cycles, freeze-thaw transfer all transferred embryos non-high That say, FET at least one high-quality included analysis. . Participants/materials, setting, methods patients underfoing cycle January December 2022. preparation protocols natural ovulatory ovulation induction hormone replacement treatment cycles. Transvaginal thickness diameter dominant follicle began 10-12th day menstrual cycle. Embryo timed accordingly frozen out. Main results role chance A total number analyzed. echo central line different between pregnant group non-pregnant group. Other parameters, such volume, peristalsis, flow statistically two groups. Then, according relationship groups clinical rate, score 0 2 respectively scored. The sum scores six items patient’s score. showed rate increased increased, when reaches 5, (58.2% versus 40.4%, P = 0.001). echogenicity functional layer more homogeneous, it did reach statistical significance. presence absence direction Limitations, reasons caution data live birth we considered proxy outcome confirm receptive endometrium. Moreover, sample size relatively small, necessary further expand verify our conclusions. Wider implications findings We developed an scoring system demonstrated validity. may aid clinicians choosing useful marker practice informing research. As Ultrasonography simple non-invasive diagnostic tool, cost will reduce. Trial registration NOT REQUIRED